Title : DNA microarray data integration by ortholog gene analysis reveals potential molecular mechanisms of estrogen-dependent growth of human uterine fibroids.

Pub. Date : 2007 Apr 2

PMID : 17407572






1 Functional Relationships(s)
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1 Secondly, estrogen may antagonize PPARgamma signaling, thought to inhibit fibroid growth and survival, at two points in the PPAR pathway: 1) through increased ANXA1 gene expression which can inhibit phospholipase A2 activity and in turn decrease arachidonic acid synthesis, and 2) by decreasing L-PGDS expression which would reduce synthesis of PGJ2, an endogenous ligand for PPARgamma. 9-deoxy-delta-9-prostaglandin D2 peroxisome proliferator activated receptor gamma Homo sapiens