Title : Microsomal prostaglandin E synthase-1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E(2) biosynthesis in vascular smooth muscle cells.

Pub. Date : 2007 Jul

PMID : 17403097






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 VSMC ability to synthesize PGE(2) and PGI(2) fitted mPGES-1 and COX-2 expression, respectively. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Results from COX-1 and COX-2 silencing and selective inhibition showed that both COX-1 and COX-2 were involved in the biosynthesis of PGE(2) and their relative contribution depended on the time of incubation with IL-1beta. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Results from COX-1 and COX-2 silencing and selective inhibition showed that both COX-1 and COX-2 were involved in the biosynthesis of PGE(2) and their relative contribution depended on the time of incubation with IL-1beta. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens