Title : Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels.

Pub. Date : 2007 Aug

PMID : 17394531






2 Functional Relationships(s)
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1 Additionally, we tested the hypothesis that mutant SOD1 increases mitochondrial-produced superoxide (O(2) (*)) levels and that SOD2 overexpression protects neurons from mutant SOD1-induced toxicity by reducing O(2) (*) levels in mitochondria. Oxygen superoxide dismutase 2 Homo sapiens
2 These elevated O(2) (*) levels in mitochondria were significantly diminished by the overexpression of SOD2. Oxygen superoxide dismutase 2 Homo sapiens