Title : XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.

Pub. Date : 2007 May 15

PMID : 17385215






4 Functional Relationships(s)
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Protein Name
Organism
1 RESULTS: U0126 increased the expression of XAF1 in a time- and dose-dependent manner. U 0126 XIAP associated factor 1 Homo sapiens
2 Activity of the putative promoter of the XAF1 gene was significantly increased by U0126 treatment and DN-MEK1 transient transfection. U 0126 XIAP associated factor 1 Homo sapiens
3 Overexpression of XAF1 was more sensitive to U0126-induced apoptosis, whereas down-regulation of XAF1 by antisense reversed U0126-induced inhibition of cell proliferation. U 0126 XIAP associated factor 1 Homo sapiens
4 Overexpression of XAF1 was more sensitive to U0126-induced apoptosis, whereas down-regulation of XAF1 by antisense reversed U0126-induced inhibition of cell proliferation. U 0126 XIAP associated factor 1 Homo sapiens