Title : Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory.

Pub. Date : 2007 Mar 23

PMID : 17382888






1 Functional Relationships(s)
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1 Here we report that MAPK and CREB-mediated transcription are negatively regulated by SCOP (suprachiasmatic nucleus [SCN] circadian oscillatory protein) and that SCOP is proteolyzed by calpain when hippocampal neurons are stimulated by brain-derived neurotrophic factor (BDNF), KCl depolarization, or NMDA. N-Methylaspartate cAMP responsive element binding protein 1 Mus musculus