Title : Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients.

Pub. Date : 2007 Apr

PMID : 17381388






2 Functional Relationships(s)
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1 The interacting mechanism likely was inhibited cytochrome P450 (CYP) 3A4 metabolism and possibly P-glycoprotein transport of simvastatin as well. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Previous reports of simvastatin-clarithromycin-related events involved additional drugs that inhibited CYP3A4 and P-glycoprotein. Simvastatin cytochrome P450 family 3 subfamily A member 4 Homo sapiens