Title : PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD.

Pub. Date : 2008 Aug

PMID : 17379359






4 Functional Relationships(s)
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1 The effect of galantamine treatment on cortical acetylcholinesterase (AChE) activity and nicotinic receptor binding was investigated by positron emission tomography (PET) in 18 patients with mild Alzheimer"s disease (AD) in relation to galantamine concentration and the patients" cognitive performances. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The effect of galantamine treatment on cortical acetylcholinesterase (AChE) activity and nicotinic receptor binding was investigated by positron emission tomography (PET) in 18 patients with mild Alzheimer"s disease (AD) in relation to galantamine concentration and the patients" cognitive performances. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Inhibition (30-40%) of cortical AChE activity was observed after 3 weeks to 12 months of galantamine treatment. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
4 In conclusion, galantamine caused sustained AChE inhibition for up to 12 months. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens