Pub. Date : 2007 May 11
PMID : 17376479
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, fine regulation of CCR is accomplished by the small molecule effectors, glucose 6-phosphate (G6P) and fructose 1,6-bisphosphate (FBP), which somehow enhance CcpA-(HPr-Ser46-P) binding to DNA. | 2-chloro-N(6)cyclopentyladenosine | fructose-bisphosphatase 1 | Homo sapiens |
| 2 | To understand the fine-tuning mechanism of these effectors, we solved the structures of the CcpA core, DeltaCcpA, which lacks the N-terminal DNA-binding domain, in complex with HPr-Ser46-P and G6P or FBP. | 2-chloro-N(6)cyclopentyladenosine | fructose-bisphosphatase 1 | Homo sapiens |
| 3 | G6P and FBP bind in a deep cleft, between the N and C subdomains of CcpA. | 2-chloro-N(6)cyclopentyladenosine | fructose-bisphosphatase 1 | Homo sapiens |
| 4 | Thus, stabilization of the closed conformation and bolstering of cross contacts between CcpA and its other corepressor, HPr-Ser46-P, provide a molecular explanation for how adjunct corepressors G6P and FBP enhance the interaction between CcpA-(HPr-Ser46-P) and cognate DNA. | 2-chloro-N(6)cyclopentyladenosine | fructose-bisphosphatase 1 | Homo sapiens |
| 5 | Thus, stabilization of the closed conformation and bolstering of cross contacts between CcpA and its other corepressor, HPr-Ser46-P, provide a molecular explanation for how adjunct corepressors G6P and FBP enhance the interaction between CcpA-(HPr-Ser46-P) and cognate DNA. | 2-chloro-N(6)cyclopentyladenosine | fructose-bisphosphatase 1 | Homo sapiens |