Title : Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

Pub. Date : 1992 Mar 1

PMID : 1737390






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
3 Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
4 Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
5 Thus, differential actions of bryostatin 1 and TPA on PKC activity and alpha-isoform level in the membrane-associated fraction of MCF-7 and MDA-MB-468 cells may account for the divergent effects of these two agents on cell growth and morphology. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens