Title : Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets.

Pub. Date : 2007 Jul

PMID : 17372274






3 Functional Relationships(s)
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1 Topical application of humulone (10 mumol) significantly inhibited TPA-induced epidermal COX-2 expression. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Mus musculus
2 The present study revealed that topical application of SP600125, a pharmacological inhibitor of c-Jun-N-terminal kinase (JNK), abrogated the activation of AP-1 and the expression of COX-2 in TPA-treated mouse skin. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Mus musculus
3 Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Mus musculus