Title : An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations.

Pub. Date : 2007 Mar 27

PMID : 17372216






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Paradoxically, we find that this autoantibody potentiates the Ca(2+)/Gq-dependent accumulation of inositol phosphates by slightly shifting the dose dependence curve of the Ca(2+) mediated activation of phosphatidylinositol turnover to the left, whereas it inhibits the Ca(2+)/Gi-dependent phosphorylation of ERK1/2 in HEK293 cells stably expressing human CaSR. Inositol Phosphates calcium sensing receptor Homo sapiens