Title : Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.

Pub. Date : 2007 Jun

PMID : 17371838






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Although comparable in level to that achieved by treatment with the p53 activators actinomycin D and nutlin-3, the increases in p53 and p21 after downregulation of Mdm2 were not sufficient to trigger cell cycle arrest. Dactinomycin tumor protein p53 Homo sapiens