Pub. Date : 2007 Jun 22
PMID : 17368617
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala. | tianeptine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | Conversely, BDNF mRNA levels were increased in the amygdala of chronic restraint stress/tianeptine rats in the absence of changes in pCREB levels when compared to non-stressed controls. | tianeptine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | Amygdalar BDNF protein increased while pCREB levels decreased in tianeptine-treated rats irrespective of stress conditions. | tianeptine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | Collectively, these results demonstrate that tianeptine concomitantly decreases pCREB while increasing BDNF expression in the rat amygdala, increases in neurotrophic factor expression that may participate in the enhancement of amygdalar synaptic plasticity mediated by tianeptine. | tianeptine | brain-derived neurotrophic factor | Rattus norvegicus |