Pub. Date : 2007 Feb
PMID : 17366743
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oleanolic acid, a pentacyclic triterpenoid, induces rabbit platelet aggregation through a phospholipase C-calcium dependent signaling pathway. | Oleanolic Acid | LOC100009319 | Oryctolagus cuniculus |
| 2 | Pretreating the platelets with U73122, a phospholipase C (PLC) inhibitor, blocked the oleanolic acid induced-aggregation, whereas acetylsalicylic acid (ASA), a cyclooxygenase (COX) inhibitor, had no effect. | Oleanolic Acid | LOC100009319 | Oryctolagus cuniculus |
| 3 | Pretreating the platelets with U73122, a phospholipase C (PLC) inhibitor, blocked the oleanolic acid induced-aggregation, whereas acetylsalicylic acid (ASA), a cyclooxygenase (COX) inhibitor, had no effect. | Oleanolic Acid | LOC100009319 | Oryctolagus cuniculus |
| 4 | Overall, these results suggest that oleanolic acid can induce platelet aggregation, which may be mediated by the stimulation of PLC-mediated cytosolic calcium mobilization. | Oleanolic Acid | LOC100009319 | Oryctolagus cuniculus |