Pub. Date : 2007 Mar
PMID : 17365862
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 2 | In this work we have investigated the ability of epinephrine to trigger the release of intracellular Ca2+ in thrombin-desensitized platelets. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 3 | Although epinephrine alone had no effect on intracellular Ca2+ mobilization, its addition to thrombin-desensitized platelets was associated to a rapid and evident secondary release of intracellular Ca2+. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 4 | Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 5 | Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 6 | Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 7 | Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 8 | These results demonstrate a direct role of thrombin binding to GPIb-IX-V in the mobilization of Ca2+ from intracellular stores, and reveal that epinephrine can restore this process in desensitized platelets, thus prolonging the effect of thrombin stimulation. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |