Title : Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.

Pub. Date : 2007 Jun

PMID : 17363696






1 Functional Relationships(s)
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1 Inhibition of p38 MAPK activity abolished the induction of COX-2 protein and PGE2 accumulation by acrolein, while suppression of extracellular signal-regulated kinase (ERK) and JNK activity had no effect on the induction of COX-2 expression in experiments using inhibitors and siRNA. Dinoprostone mitogen-activated protein kinase 1 Homo sapiens