Title : The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir.

Pub. Date : 2007 Oct

PMID : 17361121






2 Functional Relationships(s)
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1 The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir. Saquinavir ATP binding cassette subfamily B member 1 Homo sapiens
2 This genotype panel study investigated the effect of ABCB1 polymorphism in exon 26 (C3435T), exon 21 (G2677T/A), and exon 12 (C1236T) on saquinavir pharmacokinetics and on the expression and activity of P-glycoprotein (P-gp) in peripheral blood monocytic cells (PBMCs). Saquinavir ATP binding cassette subfamily B member 1 Homo sapiens