Title : Biological roles of anti-GM1 antibodies in patients with Guillain-Barré syndrome for nerve growth factor signaling.

Pub. Date : 2007 May

PMID : 17355906






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
2 The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
3 The IgGs purified from patients" sera inhibited the NGF-TrkA signaling in GM1 pre-incubated PC12 cells. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
4 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
5 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
6 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens