Title : Calcineurin-independent inhibition of the delayed rectifier K+ current by the immunosuppressant FK506 in rat hippocampal neurons.

Pub. Date : 2007 May 7

PMID : 17355875






1 Functional Relationships(s)
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1 In acutely dissociated CA1 pyramidal neurons of rat hippocampus, superfusion of FK506 (0.01-100 microM) selectively inhibited the delayed rectifier K(+) current (I(K)) with an IC(50) value of 13.2+/-4.9 microM. Tacrolimus carbonic anhydrase 1 Rattus norvegicus