Pub. Date : 1992 Feb 1
PMID : 1735448
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The serum level of alpha 1-acid glycoprotein (alpha 1-AGP) is significantly increased in various animal species by treatment with cytokines, glucocorticoids and phenobarbital. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 2 | The serum level of alpha 1-acid glycoprotein (alpha 1-AGP) is significantly increased in various animal species by treatment with cytokines, glucocorticoids and phenobarbital. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 3 | The main purpose of this study was to assess whether phenobarbital acts on alpha 1-AGP synthesis in the liver at the transcriptional or translational level. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 4 | The analysis of total hepatic RNA showed that a single injection of phenobarbital induced an 11-fold increase in phenobarbital-dependent cytochrome P450IIB mRNA, whereas seven injections of phenobarbital were required to induce a maximum 5.5-fold increase in alpha 1-AGP mRNA. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 5 | The analysis of total hepatic RNA showed that a single injection of phenobarbital induced an 11-fold increase in phenobarbital-dependent cytochrome P450IIB mRNA, whereas seven injections of phenobarbital were required to induce a maximum 5.5-fold increase in alpha 1-AGP mRNA. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 6 | The analysis of total hepatic RNA showed that a single injection of phenobarbital induced an 11-fold increase in phenobarbital-dependent cytochrome P450IIB mRNA, whereas seven injections of phenobarbital were required to induce a maximum 5.5-fold increase in alpha 1-AGP mRNA. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 7 | Hepatocytes isolated after the seventh injection of phenobarbital showed a threefold increased capacity to secrete alpha 1-AGP, corresponding to a 3.2-fold increased alpha 1-AGP mRNA content in the liver. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 8 | Hepatocytes isolated after the seventh injection of phenobarbital showed a threefold increased capacity to secrete alpha 1-AGP, corresponding to a 3.2-fold increased alpha 1-AGP mRNA content in the liver. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 9 | In conditions in which its effect on the induction of alpha 1-AGP synthesis was maximum, phenobarbital caused a 30% reduction in liver albumin mRNA and in albumin secretion by isolated hepatocytes, resulting from a 60-70% reduction in the rate of transcription of the albumin gene measured in isolated nuclei. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |
| 10 | We conclude that the effect of phenobarbital on alpha 1-AGP and albumin gene expression occurs at the transcriptional rather than the translational level. | Phenobarbital | orosomucoid 1 | Rattus norvegicus |