Pub. Date : 2007 Jan-Mar
PMID : 17346427
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We obtained the first evidence that the GFAT mRNA and protein are constitutively expressed in murine mononuclear phagocytes (Mf) and inducible by picolinic acid (PA), a catabolite of tryptophan, hypoxia and desferrioxamine (DFX). | Deferoxamine | glutamine fructose-6-phosphate transaminase 1 | Mus musculus |
| 2 | We obtained the first evidence that the GFAT mRNA and protein are constitutively expressed in murine mononuclear phagocytes (Mf) and inducible by picolinic acid (PA), a catabolite of tryptophan, hypoxia and desferrioxamine (DFX). | Deferoxamine | glutamine fructose-6-phosphate transaminase 1 | Mus musculus |
| 3 | We found that GFAT-HRE is essential for the response to hypoxia, PA or DFX and that Hypoxia Inducible Factor-1alpha (HIF-1alpha) can augment this response. | Deferoxamine | glutamine fructose-6-phosphate transaminase 1 | Mus musculus |
| 4 | Finally, we demonstrate that iron chelation is part of the mechanism by which PA and DFX activate GFAT expression. | Deferoxamine | glutamine fructose-6-phosphate transaminase 1 | Mus musculus |
| 5 | Our results provide the first indication that hypoxia, PA or DFX induce the transcription of GFAT gene in murine Mf cell lines and that the HRE of the promoter is essential for this response. | Deferoxamine | glutamine fructose-6-phosphate transaminase 1 | Mus musculus |