Title : Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity.

Pub. Date : 2007 Apr

PMID : 17339844






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 KEY RESULTS: Here, we show that preservation of ECs by EPO during oxygen-glucose deprivation (OGD) required the initial activation of the phosphatidylinositol 3-kinase (PI-3K) pathway through Akt1, since specific pharmacological blockade of Akt1 activity or gene silencing of Akt1 prevented EC protection by EPO. oxygen-glucose erythropoietin Homo sapiens