Pub. Date : 2007 Jun
PMID : 17337592
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PI3-kinase inhibition blocked HP-induced increases in Akt phosphorylation, reversed the effects of HP on OGD-induced AIF translocation and PARP-1 cleavage, blocked HP-induced survivin phosphorylation, and ultimately attenuated HP-induced protection of HBMECs from OGD. | Hematoporphyrins | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Thus HP promotes an antiapoptotic phenotype in HBMECs, in part by activating survivin via the PI3-kinase/Akt pathway. | Hematoporphyrins | AKT serine/threonine kinase 1 | Homo sapiens |