Title : Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly.

Pub. Date : 2007 Mar 1

PMID : 17328821






1 Functional Relationships(s)
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1 The LDLR of HepG2 cells incubated with conditioned medium was protected from PCSK9-mediated degradation by the addition of nocodazole or ammonium chloride, but was not protected when the conditioned medium was made hypertonic. Ammonium Chloride low density lipoprotein receptor Homo sapiens