Title : Sunitinib: from rational design to clinical efficacy.

Pub. Date : 2007 Mar 1

PMID : 17327610






1 Functional Relationships(s)
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1 Sunitinib inhibits other tyrosine kinases including, KIT, FLT3, colony-stimulating factor 1 (CSF-1), and RET, which are involved in a number of malignancies including small-cell lung cancer, GI stromal tumors (GISTs), breast cancer, acute myelogenous leukemia, multiple endocrine neoplasia types 2A and 2B, and familial medullary thyroid carcinoma. Sunitinib ret proto-oncogene Homo sapiens