Title : Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.

Pub. Date : 2007 Feb 15

PMID : 17317846






1 Functional Relationships(s)
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1 The results provide clinical implications that therapeutic targeting at the BRAF/MEK/MAP kinase pathway may be a good approach in restoring thyroid gene expression for effective radioiodine therapy for BRAF mutation-harboring PTC. Iodine-131 mitogen-activated protein kinase kinase 7 Homo sapiens