Title : Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells.

Pub. Date : 2007 Feb 15

PMID : 17308114






1 Functional Relationships(s)
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1 Moreover, COX-1/COX-2 inhibitors block ET-induced PGE(2) and VEGF secretion, matrix metalloproteinase (MMP) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens