Pub. Date : 2007 May
PMID : 17308032
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin increases the potency of glycine at ionotropic glycine receptors. | Glycine | insulin | Homo sapiens |
| 2 | Whole-cell patch-clamp recordings showed that insulin reversibly enhanced current evoked by exogenous glycine and increased the amplitude of spontaneous glycinergic miniature inhibitory postsynaptic currents recorded in cultured spinal neurons. | Glycine | insulin | Homo sapiens |
| 3 | Insulin (1 microM) also shifted the glycine concentration-response plot to the left and reduced the glycine EC(50) value from 52 to 31 microM. | Glycine | insulin | Homo sapiens |
| 4 | Together, these results show that insulin has a novel regulatory action on the potency of glycine for ionotropic glycine receptors. | Glycine | insulin | Homo sapiens |