Title : Hypermethylation of adenosine triphosphate-binding cassette transporter genes in primary hyperparathyroidism and its effect on sestamibi imaging.

Pub. Date : 2007 May

PMID : 17299072






6 Functional Relationships(s)
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1 CONTEXT: Retention of technetium-(99m)-sestamibi ((99m)Tc-sestamibi) by parathyroid adenomas appears to be due to the loss of at least one membrane transporter, multidrug resistance 1 (MDR1), and possibly another, multidrug resistance-associated protein 1 (MRP1). Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens
2 CONTEXT: Retention of technetium-(99m)-sestamibi ((99m)Tc-sestamibi) by parathyroid adenomas appears to be due to the loss of at least one membrane transporter, multidrug resistance 1 (MDR1), and possibly another, multidrug resistance-associated protein 1 (MRP1). Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens
3 CONTEXT: Retention of technetium-(99m)-sestamibi ((99m)Tc-sestamibi) by parathyroid adenomas appears to be due to the loss of at least one membrane transporter, multidrug resistance 1 (MDR1), and possibly another, multidrug resistance-associated protein 1 (MRP1). Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens
4 CONTEXT: Retention of technetium-(99m)-sestamibi ((99m)Tc-sestamibi) by parathyroid adenomas appears to be due to the loss of at least one membrane transporter, multidrug resistance 1 (MDR1), and possibly another, multidrug resistance-associated protein 1 (MRP1). Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens
5 Among all glands, hypermethylation for MDR1 was more likely in (99m)Tc-sestamibi-positive scans (P < 0.001). Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens
6 CONCLUSION: In parathyroid tissue, hypermethylation of the MDR1 gene decreases its expression and is associated with increased detection of parathyroid adenomas by (99m)Tc-sestamibi parathyroid scans. Technetium Tc 99m Sestamibi ATP binding cassette subfamily B member 1 Homo sapiens