Title : Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death.

Pub. Date : 2007 Mar 30

PMID : 17292807






2 Functional Relationships(s)
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1 Lamotrigine significantly attenuated the rotenone- or MPP+-induced mitochondrial damage leading to caspase-3 activation, increased oxidative stress and cell death. Lamotrigine caspase 3 Rattus norvegicus
2 The results show that lamotrigine seems to reduce the cytotoxicity of rotenone and MPP+ by suppressing the mitochondrial permeability transition formation, leading to cytochrome c release and subsequent activation of caspase-3. Lamotrigine caspase 3 Rattus norvegicus