Title : Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease.

Pub. Date : 2007 Feb

PMID : 17285465






1 Functional Relationships(s)
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1 Devoid of any direct cyclooxygenase inhibition, which is associated with the more toxic S-enantiomer of flurbiprofen, (R)-flurbiprofen appears to modulate gamma-secretase, the enzyme that cleaves the C-terminal portion of the malignant Abeta(1-42) peptide out of amyloid precursor protein. Flurbiprofen amyloid beta precursor protein Homo sapiens