Title : Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.

Pub. Date : 2007 Feb

PMID : 17267660






1 Functional Relationships(s)
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1 In prostate cancer and Wilms" tumor xenografts, halofuginone, but not the respective chemotherapies, inhibited the synthesis of collagen type I, alpha-smooth muscle actin, transgelin, and cytoglobin, all of which are characteristics of activated myofibroblasts. halofuginone cytoglobin Homo sapiens