Pub. Date : 2007 Apr
PMID : 17267622
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human CYP2A6 is responsible for the metabolism of nicotine and its genetic polymorphisms affect smoking behavior and risk of lung cancer. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | The plasma cotinine/nicotine ratio in subjects possessing the novel CYP2A6 gene duplication with the CYP2A6*1 allele (10.8 +/- 7.0, n = 4) was 1.4-fold higher than that in homozygotes of the wild type (8.0 +/- 5.0, n = 87), although the difference was not statistically significant. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | The plasma cotinine/nicotine ratio in subjects possessing the novel CYP2A6 gene duplication with the CYP2A6*1 allele (10.8 +/- 7.0, n = 4) was 1.4-fold higher than that in homozygotes of the wild type (8.0 +/- 5.0, n = 87), although the difference was not statistically significant. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | The findings in the present study suggested that the novel duplicated CYP2A6 allele, which is specific for African Americans, would increase nicotine metabolism and may affect smoking behavior. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |