Title : Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2.

Pub. Date : 2007 Mar 16

PMID : 17266931






1 Functional Relationships(s)
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1 These mutations improve the K(M) for thymidine, increasing the catalytic activity of L78F/L116M-TK2 4.4-fold, yet leaving the activity for deoxycytidine or the purine nucleosides unchanged. Deoxycytidine thymidine kinase 2 Homo sapiens