Title : Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2.

Pub. Date : 2007 Mar 16

PMID : 17266931






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TK2 is strictly pyrimidine-specific, whereas its phylogenetic relative, the Drosophila melanogaster deoxyribonucleoside kinase (DmdNK), shows higher activity and broader specificity towards both pyrimidines and purines. Purines deoxyribonucleoside kinase Drosophila melanogaster