Title : Effect of atorvastatin and pravastatin on platelet inhibition by aspirin and clopidogrel treatment in patients with coronary stent thrombosis.

Pub. Date : 2007 Feb 1

PMID : 17261397






3 Functional Relationships(s)
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1 Previous laboratory studies have shown a possible drug-drug interaction of statins metabolized by cytochrome P450 3A4 and clopidogrel (prodrug metabolized by cytochrome P450 3A4), resulting in an impaired inhibitory effect of clopidogrel on platelet aggregation. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Previous laboratory studies have shown a possible drug-drug interaction of statins metabolized by cytochrome P450 3A4 and clopidogrel (prodrug metabolized by cytochrome P450 3A4), resulting in an impaired inhibitory effect of clopidogrel on platelet aggregation. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Previous laboratory studies have shown a possible drug-drug interaction of statins metabolized by cytochrome P450 3A4 and clopidogrel (prodrug metabolized by cytochrome P450 3A4), resulting in an impaired inhibitory effect of clopidogrel on platelet aggregation. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens