Title : The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin.

Pub. Date : 2007 Feb

PMID : 17261087






1 Functional Relationships(s)
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1 Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen was replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His were cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen was cleaved at residue 10. Proline angiotensinogen Homo sapiens