Title : Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: both immunosuppressants augment Ly-6E antigen induction by interferon-gamma in the presence of ionomycin.

Pub. Date : 1991

PMID : 1726093






3 Functional Relationships(s)
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1 Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: both immunosuppressants augment Ly-6E antigen induction by interferon-gamma in the presence of ionomycin. Tacrolimus lymphocyte antigen 6 complex, locus E Mus musculus
2 Cyclosporin A or FK-506 also markedly affected Ly-6E induction when the cultures were co-treated with the calcium ionophore, ionomycin. Tacrolimus lymphocyte antigen 6 complex, locus E Mus musculus
3 Therefore, through mechanisms apparently related to those involved in their immunosuppressive action, both CsA and FK-506 convert the negative effect of ionomycin on IFN-gamma-mediated Ly-6E induction into an overall positive effect. Tacrolimus lymphocyte antigen 6 complex, locus E Mus musculus