Title : The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin.

Pub. Date : 2007 Mar 16

PMID : 17257585






5 Functional Relationships(s)
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1 Tin mesoporphyrin (SnMP), a competitive heme oxygenase (HO) inhibitor, also induces HO-1 mRNA and protein expression by a mechanism that is not fully understood. tin mesoporphyrin heme oxygenase 1 Homo sapiens
2 Tin mesoporphyrin (SnMP), a competitive heme oxygenase (HO) inhibitor, also induces HO-1 mRNA and protein expression by a mechanism that is not fully understood. tin mesoporphyrin heme oxygenase 1 Homo sapiens
3 Transfection of Bach1 shRNA in Hepa cells raised basal HO-1 expression significantly, and SnMP treatment further increased HO-1 mRNA. tin mesoporphyrin heme oxygenase 1 Homo sapiens
4 In conclusion, SnMP induces HO-1 expression not only by de-repressing the HO-1 promoter by binding Bach1, but also by accelerating Bach1 degradation. tin mesoporphyrin heme oxygenase 1 Homo sapiens
5 In conclusion, SnMP induces HO-1 expression not only by de-repressing the HO-1 promoter by binding Bach1, but also by accelerating Bach1 degradation. tin mesoporphyrin heme oxygenase 1 Homo sapiens