Title : Isomeric N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent P-glycoprotein (Pgp)-dependent multidrug resistance (MDR) inhibitors.

Pub. Date : 2007 Feb 22

PMID : 17256837






1 Functional Relationships(s)
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1 Among them, compound 1d, on anthracycline-resistant erythroleukemia K562 cells, is able to completely reverse Pgp-dependent MDR at low nanomolar concentration. Anthracyclines ATP binding cassette subfamily B member 1 Homo sapiens