Title : Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-alpha from LPS-stimulated monocytes/macrophages.

Pub. Date : 2007 Mar

PMID : 17253143






2 Functional Relationships(s)
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1 The effects of atRA on LPS-induced mRNA expression of IL-10, IL-12p40, TNF-alpha, IL-18, and TGF-beta in the THP-1 monocyte/macrophage cell line and in cord blood mononuclear cells were measured by competitive RT-PCR. Tretinoin GLI family zinc finger 2 Homo sapiens
2 The addition of atRA to cell cultures potentiated the LPS-induced IL-10 mRNA expression and the number of IL-10 secreting cells from THP-1 cells and cord blood mononuclear cells. Tretinoin GLI family zinc finger 2 Homo sapiens