Title : Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway.

Pub. Date : 2007 Jan

PMID : 17241427






4 Functional Relationships(s)
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1 OBJECTIVE: Arachidonic acid, a precursor of prostaglandins (PGs), is released by phospholipase A2 (PLA2) and plays an important role in biological reactions. Arachidonic Acid phospholipase A2, group IB, pancreas Mus musculus
2 OBJECTIVE: Arachidonic acid, a precursor of prostaglandins (PGs), is released by phospholipase A2 (PLA2) and plays an important role in biological reactions. Arachidonic Acid phospholipase A2, group IB, pancreas Mus musculus
3 CONCLUSION: The present results indicate that exogenous arachidonic acid stimulated the activity of PLA2, leading to the new release of membranous arachidonic acid. Arachidonic Acid phospholipase A2, group IB, pancreas Mus musculus
4 Our results provide a new insight into the molecular mechanisms by which exogenous arachidonic acid plays a role as a paracrine/autocrine amplifier of PGE2 biosynthesis by coupling with PLA2 and COX-2. Arachidonic Acid phospholipase A2, group IB, pancreas Mus musculus