Title : A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Pub. Date : 2006 Dec 15

PMID : 17240976






1 Functional Relationships(s)
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1 A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. Vanadates AKT serine/threonine kinase 1 Homo sapiens