Pub. Date : 2007 Apr
PMID : 17240182
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: We describe assays for plasma AADC enzyme activity using both of its substrates, 5-hydroxytryptophan (5-HTP) and 3,4-dihydroxyphenylalanine (L-dopa). | 5-Hydroxytryptophan | dopa decarboxylase | Homo sapiens |
| 2 | METHODS: We describe assays for plasma AADC enzyme activity using both of its substrates, 5-hydroxytryptophan (5-HTP) and 3,4-dihydroxyphenylalanine (L-dopa). | 5-Hydroxytryptophan | dopa decarboxylase | Homo sapiens |
| 3 | RESULTS: AADC enzyme activity in control plasma on average is a factor 8-12 higher with L-dopa as substrate than with 5-HTP. | 5-Hydroxytryptophan | dopa decarboxylase | Homo sapiens |
| 4 | In AADC deficient patients, the enzyme activity towards both substrates, L-dopa and 5-HTP, are equally decreased, as are the CSF concentrations of HVA, 5-HIAA and MHPG, whereas heterozygotes have intermediate AADC activity levels. | 5-Hydroxytryptophan | dopa decarboxylase | Homo sapiens |