Title : [The relationship between P53 and hypoxia-inducible transcription factor-1alpha in the placenta of patient with intrahepatic cholestasis of pregnancy under acute hypoxic condition].

Pub. Date : 2006 Nov

PMID : 17236590






3 Functional Relationships(s)
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1 RESULTS: Under the condition of normal concentration oxygen, P53 was highly expressed in the placenta of pregnant women with ICP (P < 0.01), however the HIF-1alpha expression was not up to higher than in normal control. Oxygen tumor protein p53 Homo sapiens
2 Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P < 0.05 and P < 0.001 respectively). Oxygen tumor protein p53 Homo sapiens
3 Under the condition of lower concentration oxygen (2% O2), the HIF-1alpha and P53 expressions were detected from the placental villous tissues cultured for 4 h of normal control and patient with ICP, and with HIF-1alpha and P53 proteins increased in the placenta of pregnant women with ICP (P < 0.05 and P < 0.001 respectively). Oxygen tumor protein p53 Homo sapiens