Pub. Date : 2007 Apr
PMID : 17235328
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. | Dimethyl Fumarate | heme oxygenase 1 | Homo sapiens |
| 2 | Supplementation with exogenous glutathione (GSH), which is known to bind DMF, prevented both HO-1 induction as well as the anti-inflammatory effects of DMF. | Dimethyl Fumarate | heme oxygenase 1 | Homo sapiens |
| 3 | These results suggest that DMF acts as active compound within the FAE mixture and at least partially mediates its immunomodulatory activity by the induction of the anti-inflammatory stress protein HO-1 ascribed to the functional depletion of reduced GSH. | Dimethyl Fumarate | heme oxygenase 1 | Homo sapiens |