Title : Human renal organic anion transporter 4 operates as an asymmetric urate transporter.

Pub. Date : 2007 Feb

PMID : 17229912






2 Functional Relationships(s)
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Protein Name
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1 PAH and glutarate are not taken up by HEK293-hOAT4 cells, but they trans-stimulated 6-CF and [(3)H]ES uptake, indicating an asymmetric interaction of hOAT4 with these substrates. p-Aminohippuric Acid solute carrier family 22 member 11 Homo sapiens
2 In chloride-free medium, HEK293-hOAT4-mediated [(3)H]PAH efflux was almost abolished, whereas addition of ES restored it comparable to Ringer solution, consistent with a physiologic ES/PAH or PAH/Cl(-) exchange mode of hOAT4. p-Aminohippuric Acid solute carrier family 22 member 11 Homo sapiens