Title : Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation.

Pub. Date : 2007 May 1

PMID : 17223084






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone. Phenolphthalein UDP glucuronosyltransferase family 2 member B15 Homo sapiens
2 A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone. Phenolphthalein UDP glucuronosyltransferase family 2 member B15 Homo sapiens
3 Derived apparent K(m) values for testosterone and phenolphthalein glucuronidation by UGT2B7-15((61-194))-7 were similar in magnitude to those determined for UGT2B15. Phenolphthalein UDP glucuronosyltransferase family 2 member B15 Homo sapiens