Title : Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.

Pub. Date : 2007 Mar

PMID : 17210646






5 Functional Relationships(s)
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1 Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens
2 Furthermore, after cAMP stimulation, both c-Jun and Jun N-terminal kinase (JNK) were phosphorylated through HIPK3. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens
3 Furthermore, after cAMP stimulation, both c-Jun and Jun N-terminal kinase (JNK) were phosphorylated through HIPK3. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens
4 Thus, we have defined HIPK3-mediated JNK activity and c-Jun phosphorylation as important events that increase SF-1 activity for CYP11A1 transcription in response to cAMP. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens
5 This finding has linked three common factors, HIPK3, JNK, and c-Jun, to the cAMP signaling pathway leading to increased steroidogenic gene expression. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens