Title : involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene.

Pub. Date : 2007 Apr

PMID : 17204581






1 Functional Relationships(s)
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1 Ovarian follicle disruption in mice caused by 7,12-dimethylbenz[a]anthracene (DMBA) is attributed to its bioactivation by CYP1B1 to a 3,4-epoxide which is then hydrolyzed to form a 3,4-diol by microsomal epoxide hydrolase (mEH). 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus